Abstract
Summary. LDH, MDH and COT isoenzymes were studied by means of electrophoresis and chromatography in preparations of lymphocytes from peripheral blood and from foetal and adult thymus and spleen. In both foetal spleen and thymus LDH has an undifferentiated pattern, whereas both COT and MDH are characterized by the predominance of the cytoplasmic fraction: these results suggest that in foetal life lymphocytes do not receive a maturative imprinting passing from thymus to spleen. The prevalence of the anodal LDH fractions was shown in lymphocytes from peripheral blood and from adult spleen and thymus; nevertheless, since zone I is not the largest, this pattern is not completely differentiated and this behaviour is related to the potentialities of the lymphocyte in every stage of its development. COT and MDH show different characteristics in lymphocytes from adult spleen, adult thymus and peripheral blood: in thymocytes the cytoplasmic fraction is the largest, whereas a complete inversion of the pattern was revealed in splenocytes and peripheral lymphocytes, with marked predominance of the mithocondrial fractions. The hypothesis is suggested that lymphocytes, passing from thymus to spleen and peripheral blood, are sensitive to the influence of ambient imprintings and inducers, which modify their biochemical characteristics.
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