Abstract
Total lactate dehydrogenase activity in the synovial tissue from 19 patients with rheumatoid arthritis and from 13 control subjects was measured. In addition, isoenzyme pattern and the subunit M percentage were determined. Total enzyme activity in synovium was increased about two-fold in rheumatoid arthritis when compared to controls. The main LDH isoenzymes both in controls and m rheumatoid arthritis were LDH 4 and LDH 5, the most cathodically migrating ones. Increased LDH activity was observed in all isoenzyme fractions, and the isoenzyme pattern in rheumatoid synovial tissue did not differ from that in specimens from control subjects. Consequently, no difference m the subunit M percentage, calculated from the isoenzyme pattern, could be observed. The results suggest that anaerobic metabolism is increased in the synovial tissue in rheumatoid arthritis.
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