Abstract
The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.
Highlights
Causes of death in children with severe sepsis include septic shock, end organ damage and multiple organ dysfunction syndrome (MODS)[1]
About 91.6% of the area was under curve which was statistically significant with a cut off value of lactate clearance less than or equal to 12.7%
Lactate at zero hours and six hours was significantly more among non-survivors compared to survivors
Summary
Causes of death in children with severe sepsis include septic shock, end organ damage and multiple organ dysfunction syndrome (MODS)[1]. Hypoperfusion leads to global tissue hypoxia, pyruvate no longer entering mitochondria for aerobic metabolism but being preferentially reduced to lactate, resulting in lactate accumulation in the blood[3]. A study used a cutoff point of >10% within the first 6 hours of treatment, and reported that any increase in lactate clearance by 10% reduced mortality in adults with sepsis[4]. Increased serum lactate level is indicative of anaerobic metabolism caused by tissue hypoxia, and is a good marker to assess tissue perfusion in sepsis. A state of hyperlactataemia (serum lactate >2 mmol/L) is a cardinal sign of sepsis[5]. The majority of research with serum lactate and lactate clearance in sepsis has been conducted in adults and paediatric data is scarce.
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