Lacrimal Gland Adenocarcinoma with Apocrine Metaplasia: A Case Report

Nishida Manabu,Takeno Sachio,Kono Takashi,Ishino Takashi,Hamamoto Takao,Taruya Takayuki,Ueda Tsutomu

doi:10.36959/605/532

Abstract

We present the case of lacrimal gland adenocarcinoma with apocrine metaplasia and a literature review for similar cases. A 65-year-old male with painless eyelid swelling was admitted to our hospital. A physical examination revealed tumor on the caudal side of the left orbital cavity, and a biopsy indicated apocrine adenocarcinoma. The patient underwent a total left orbital exenteration with eyelid resection and reconstruction using a deep inferior epigastric perforator skin flap. The pathological evaluation led to a definitive diagnosis of lacrimal gland adenocarcinoma with apocrine metaplasia. Lacrimal carcinomas are rare in the head and neck region, so there are few studies of lacrimal gland carcinoma with apocrine metaplasia. The rarity hinders extensive elucidation of the pathological characteristics and evidence-based treatment strategies.

Highlights

Tumors arising from lacrimal glands, which are rare and account for 9% of all orbital tumors, can be classified into epithelial (40%) and lymphoid (60%) tumors [1]
Adenocystic carcinoma is the most frequent orbital epithelial malignancy, lacrimal gland adenocarcinoma has a worse prognosis than adenocystic carcinoma [3]
We describe the case of a patient with lacrimal gland adenocarcinoma, originating from the inferior eyelid, who was successfully treated with surgery and postoperative radiochemotherapy

Summary

Introduction

Tumors arising from lacrimal glands, which are rare and account for 9% of all orbital tumors, can be classified into epithelial (40%) and lymphoid (60%) tumors [1]. Metaplasia, Adenocarcinoma, Lacrimal gland, Epigastric skin flap Lacrimal gland adenocarcinoma is extremely rare, comprising 2.8% of all epithelial tumors of the orbital cavity [2]. Adenocystic carcinoma is the most frequent orbital epithelial malignancy, lacrimal gland adenocarcinoma has a worse prognosis than adenocystic carcinoma [3].

Results

Conclusion