LACK OF VITAMIN D AND AUTOIMMUNE DISEASES OF THE THYROID - EVIDENCES BASED ON META-ANALYSIS

Geovana Batista Rubin,Xisto Sena Passos,Paulo Alex Neves Da Silva,Antonio Márcio Teodoro Cordeiro Silva,Natália Menezes Silva,Lucas Cândido Gonçalves

doi:10.12957/ric.2021.56913

Geovana Batista Rubin, Xisto Sena Passos + Show 4 more

Open Access

https://doi.org/10.12957/ric.2021.56913

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Abstract

To verify whether there is a difference between serum vitamin D averages in patients with Graves' disease and Hashimoto's thyroiditis, when compared with a group of healthy individuals. This is a systematic review and meta-analysis according to the PRISMA protocol. The test of difference of means with random effect and chi-square of heterogeneity was performed, co nsidering an alpha <0.05 for acceptance of the hypotheses. The tests were performed using the STATA ® 16.0 software. There were differences between serum vitamin D averages: group with Graves' disease compared to healthy individuals (Mean = 10.06; 95% CI =0.99-19.14); Group with Hashimoto's disease compared to healthy individuals (Mean = 12.49; 95% CI = 5,9 - 19,79); group of children with Hashimoto compared to healthy children, (Mean = 19.46; 95% CI = 10.25-28.68). The mean serum vitamin D levels were significantly higher in healthy individuals, demonstrating that the depletion of this nutrient may be related to the pathophysiological process of these diseases, taking into account the immunomodulatory function that this vitamin has.

Highlights

Autoimmune diseases are characterized by the absence of immunological tolerance, caused by the combination of environmental and genetic factors, the knowledge about the function of each of these susceptibility factors is not yet precise (MERRILL; MINUCCI, 2018; WEETMAN, 2003)
In Graves' disease (GD) there is a slight infiltration of lymphocytes, with the involvement of TCD4 + helper cells, known as T helper 2 (Th2), which stimulates the production of antibodies binding to thyroid stimulating hormone (TSH) receptors
Articles published in the databases were accessed: Latin American Literature and Caribbean Health Sciences (LILACS), Scientific Electronic Library Online (SciELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) and PubMed, considering articles published from 2002 to 2020, giving preference to articles published in the last four years

Summary

INTRODUCTION

Autoimmune diseases are characterized by the absence of immunological tolerance, caused by the combination of environmental and genetic factors, the knowledge about the function of each of these susceptibility factors is not yet precise (MERRILL; MINUCCI, 2018; WEETMAN, 2003). They involve phenotype factors, of which the main diseases they represent are Hashimoto's thyroiditis (HT) and Graves' disease (GD) (RAGUSA et al, 2019; LAZARUS; PARKES, 2002). The objective was to assess the difference between the mean serum vitamin D levels, in groups of individuals diagnosed with HT and GD, comparing them with individuals without the diseases

MATERIAL AND METHODS

RESULTS AND DISCUSSION

CONCLUSION