Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result.

Abstract

The aim of this study was to assess the incidence and risk factors of intraventricular hemorrhage (IVH) as well as the role of cord blood erythropoietin (EPO) level in predicting the possibility of IVH in premature neonates. This prospective study included 140 preterm neonates born at hospitals affiliated to Shiraz University of Medical Sciences from May 2014 to April 2015. Complete blood count and cord blood EPO level was measured after birth. Brain ultrasonography was performed at 3 and 7-10days after birth in these newborns. Brain ultrasonography showed IVH in 8.57% (12/140) until the third day and 20% (28/140) at 7-10days of life in premature neonates. Early gestational age, low birth weight, low Apgar score, and failure to give prenatal steroid were significant risk factors for developing IVH. The mean level of cord blood EPO was 20.95 ± 21.09mIU/mL in premature newborns without IVH and 15.82 ± 17.11mIU/mL with IVH. There was no correlation between the cord blood EPO and IVH in premature newborns. Antenatal steroids therapy should be encouraged among women at risk of premature delivery. Our results showed that the cord blood EPO was not correlated with IVH in preterm neonates and further research is required to assess this relationship.