Abstract
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
Highlights
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection
To determine whether protection would extend to the Ebola virus (EBOV) hamster model, during 2013–2014 we investigated chloroquine treatment in this model and attempted to repeat previous in vitro findings and findings in the mouse model
Despite some activity of chloroquine against EBOV in vitro, we observed no benefit to its administration in the mouse and hamster models
Summary
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. This dosing regimen resulted in survival of 85% of mice after infection with mouse-adapted (MA) EBOV [8]. To determine whether protection would extend to the EBOV hamster model, during 2013–2014 we investigated chloroquine treatment in this model and attempted to repeat previous in vitro findings and findings in the mouse model. Six-week-old BALB/c mice or Syrian hamsters (both from Harlan, Indianapolis, IN, USA) were inoculated intraperitoneally with 100 50% lethal dose of MA EBOV.
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