Abstract
Lack of Predictive Value of Ovarian Reserve Tests for Pregnancy Likelihood. The Huge Difference Between Quantity and Quality
Highlights
Delayed childbearing is a common feature in couples visiting fertility clinics
Our data show that age is the most important variable defining the probability of ongoing pregnancy and that neither antral follicle count (AFC) nor anti-Müllerian hormone (AMH) can be used as criteria for assisted reproductive technologies (ARTs) exclusion, but as a tool for counselling and proposing different strategies such as oocyte accumulation
Since endovaginal ultrasound evaluation is usually performed during the investigation of infertile women, we believe that AFC should be definitely included as a routine test of ovarian reserve in pre-ART evaluation
Summary
Delayed childbearing is a common feature in couples visiting fertility clinics. Poorer results could be expected in terms of pregnancy rates due to two different factors related to age: declining of follicular pool (quantity) and oocyte quality [1]. The success of in vitro fertilization (IVF) depends to a large extent on both, the number and quality of oocytes obtained at the time of oocyte retrieval after controlled ovarian stimulation (COS) [2]. Number of oocytes may be predicted by using ovarian functional reserve tests (ORT), chance of pregnancy resulting in a healthy newborn depends on factors not directly related to number of oocytes.
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