Abstract
Abstract The cestode Echinococcus multilocularis (E. multilocularis) infection, a serious health problem worldwide, causes alveolar echinococcosis (AE), a tumor-like disease predominantly located in the liver. Until now, there have been few studies to explore how PD-1 contributes to parasite’s escape from immune attack and how it might be reversed. In this study, we found that liver PD-1 expression was significantly enhanced in AE patients. Compared to E. multilocularis infected wild-type mice, we found lesion’s weights in the liver were significantly deceased (101.20±43.12mg vs 393.70±123.5 mg, P<0.05) and lesion’s volumes were significantly lower (82.17±28.43 mm3 vs 429.30±148.30 mm3, P<0.05) in E. multilocularis infected PD-1 knockdown mice. This study demonstrates blocking PD-1 may suppress the growth of E. multulocularis in mice, and represent a possible approach to E. multilocularis immunotherapy.
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