Abstract
The NO/cGMP signal transduction pathway plays an important role in the control of smooth muscle function. NO-sensitive guanylyl cyclase (NO-GC) is the main target of the messenger molecule NO produced by NO synthases. Stimulation of NO-GC by NO results in the synthesis of the second messenger cGMP. cGMP-mediated activation of cGMP-dependent protein kinase leads to the phosphorylation of various target proteins which finally induce the relaxation of smooth muscle. Several smooth muscle-containing tissues are innervated by non-adrenergic non-cholinergic (NANC) neurons. Release of NO from these neurons is known to mediate relaxation.
Highlights
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
NO-sensitive guanylyl cyclase (NO-GC) is the main target of the messenger molecule NO produced by NO synthases
Stimulation of NO-GC by NO results in the synthesis of the second messenger cGMP. cGMP-mediated activation of cGMP-dependent protein kinase leads to the phosphorylation of various target proteins which induce the relaxation of smooth muscle
Summary
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. . Lack of NO-mediated NANC relaxation in mice deficient in NO-sensitive guanylyl cyclase Dieter Groneberg*, Doris Koesling and Andreas Friebe Address: Institut für Pharmakologie, Ruhr-Universität Bochum, Bochum, Germany
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