Abstract
Background Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, hyperalgesia and allodynia. Several works have demonstrated that selective NOS2 inhibitors might reverse the hypersensitivity to pain induced by neuropathy [1,2]. Although these studies suggest a potential role of NOS2 in the modulation of neuropathic pain, the exact involvement of NOS2 in the development of peripheral neuropathic pain remains unclear. The aim of this study is to investigate the involvement of nitric oxide synthesized by NOS2 in the development and expression of neuropathic pain after total sciatic nerve injury.
Highlights
Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, hyperalgesia and allodynia
The aim of this study is to investigate the involvement of nitric oxide synthesized by NOS2 in the development and expression of neuropathic pain after total sciatic nerve injury
In wild type (WT) mice, the chronic constriction of the sciatic nerve led to a neuropathic pain syndrome characterized by a marked and long lasting reduction of the paw withdrawal thresholds to mechanical and thermal stimuli
Summary
Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, hyperalgesia and allodynia. Email: Olga Pol* - opol@santpau.es * Corresponding author from 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Regensburg, Germany. Published: 11 August 2009 BMC Pharmacology 2009, 9(Suppl 1):P24 doi:10.1186/1471-2210-9-S1-P24
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