Abstract
SMAD7 has been identified as a functional candidate gene for colorectal cancer (CRC). SMAD7 protein is a known antagonist of the transforming growth factor beta (TGF-β) signaling pathway which is involved in tumorigenesis. Polymorphisms in SMAD7 may thus alter cancer risk. The aim of this study was to investigate the influence of a SMAD7 gene polymorphism (rs2337107) on risk of CRC and clinicopathological features in an Iranian population. In total, 210 subjects including 105 patients with colorectal cancer and 105 healthy controls were recruited in our study. All samples were genotyped by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of colorectal cancer and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs2337107 and the risk of colorectal cancer. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). Although there was not any association between genotypes and disorder, CT was the most common genotype in this population. This genotype prevalence was also higher in the patients with well grade (54.9%) and colon (72.0%) tumors. Our results provide the first evidence that this polymorphism is not a potential contributor to the risk of colorectal cancer and clinicopathological features in an Iranian population, and suggests the need of a large-scale case-control study to validate our results.
Highlights
Colorectal cancer (CRC) as the third most common cancer brings about the fourth cause of worldwide cancer mortality (Jemal et al, 2011; Shemirani et al, 2011)
SMAD7 protein is a known antagonist of the transforming growth factor beta (TGF-b) signaling pathway which is involved in tumorigenesis
Our results provide the first evidence that this polymorphism is not a potential contributor to the risk of colorectal cancer and clinicopathological features in an Iranian population, and suggests the need of a large-scale case-control study to validate our results
Summary
Colorectal cancer (CRC) as the third most common cancer brings about the fourth cause of worldwide cancer mortality (Jemal et al, 2011; Shemirani et al, 2011). According on World Health Organization (WHO) reports, CRC is one of the common diseases in an Asian population (Moghimi-Dehkordi et al, 2012; Haerian et al, 2014). Numerous risk factors and causes have been taken into account for CRC, genetic component has a great contribution on CRC development. To emphasize this fact, nearly 35% of total cases have been reflected by twin- and family based studies (Lichtenstein et al, 2000)
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