Lack of influence of low-dose acetylsalicylic acid (100 mg daily) on platelet survival time, β-thromboglobulin and platelet factor 4 in patients with peripheral arterial occlusive disease

Abstract

In this study we investigated the influence of low-dose (100 mg daily) acetylsalicylic acid (ASA) on 111-In-platelet survival time (PST) and on plasma levels of β-thromboglobulin (β-TG) and platelet factor 4 (PF 4) in 30 patients (median age: 60 years) with arteriographically proven peripheral arterial occlusive disease in a chronic stable phase. We observed no significant changes of PST during therapy with ASA (weighted mean: 169.8 → 166 [median] hours; multiple hit: 168.3 → 170.6 hours), and also the plasma levels of B-TG (median: 31.8 → 32.3 ng/ml) and of PF 4 (3.6 → 3.9 ng/ml) remained unchanged.