Abstract
To systematically summarize the association between the X-ray repair cross complementing 3 (XRCC3) gene polymorphism and oral cancer susceptibility by meta-analysis. Databases including PubMed, EMbase, CNKI, VIP and WanFang Data were searched to identify case-control studies concerning the association between an XRCC3 gene polymorphism and the risk of oral cancer from the inception to June 2014. Two reviewers independently screened the literature according to the criteria, extracted the data and assessed the quality. Then meta-analysis was performed using Stata 11.0 software. Seven published case-control studies including 775 patients with oral cancer and 1922 controls were selected. Associations between the rs861539 polymorphism and overall oral cancer risk were not statistically significant in all kinds of comparison models (CT vs CC: OR=0.94, 95%CI=0.74-1.18; TT vs CC: OR=0.94, 95%CI=0.64- 1.38; dominant model: OR=0.95, 95%CI=0.76-1.18; recessive model: OR=0.94, 95%CI=0.69-1.29; allele T vs C: OR=0.97, 95%CI=0.84-1.11). In the stratified analysis by ethnicity, no significant associations were found among Asians and Caucasians. On stratification by tumor type, no significant associations were found for cancer and oral premalignant lesions. The XRCC3 gene polymorphism was not found to be associated with the risk of oral cancer. Considering the limited quality of the included case-control studies, more high quality studies with large sample size are needed to verify the above conclusion.
Highlights
Oral cancer is the sixth most frequent cancer worldwide and an estimated 263,900 new cases and 128,000 deaths from oral cavity cancer occurred in 2008 worldwide (Jemal et al, 2011)
The capacity for DNA repair is essential in maintaining cellular functions and homeostasis; this capacity can be altered based on DNA sequence variations in DNA repair genes, which may contribute to the onset of cancer
Study selection and data extraction Eligible studies were selected according to the following explicit inclusion criteria: (a) evaluation of the rs861539 polymorphism and oral cancer or oral carcinoma susceptibility, (b) using the method of a case-control study, (c) There was sufficient published data for the computation of odds ratios (ORs) with 95% confidence intervals (95%CIs)
Summary
Oral cancer is the sixth most frequent cancer worldwide and an estimated 263,900 new cases and 128,000 deaths from oral cavity cancer (including lip cancer) occurred in 2008 worldwide (Jemal et al, 2011). Recent genetic association studies on cancer risk have focused on the effects of single-nucleotide polymorphisms in some genes Several of these genes have included DNA repair genes, which are increasingly studied because they have a critical role in maintaining genomic integrity. These polymorphisms are only slightly associated with cancer risk at the level of the individual, the polymorphisms are prevalent at the population level and may contribute to the risk of a given population for cancer (Matullo et al, 2001). We perform an updated meta-analysis on all available case-control studies to investigate the relationship between rs861539 polymorphism in XRCC3 gene and the susceptibility of oral cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
