Abstract
The way that allogeneic hematopoietic stem cells (HSC) resist engraftment is not completely understood. Natural killer cells (NK) and lymphocytes are thought to mediate the allograft barrier in mice that are mismatched at the major histocompatibility complex (MHC). The clearing of niche space is also thought to be required for donor cell engraftment. Here we attempt to dissect the relative contribution of these host elements to hematopoietic resistance using genetically defective Rag2−/− (H2b) mice lacking T and B cells, or Rag2γc−/− (H2b) mice lacking in T, B, and NK cells as recipients.
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