Lack of habituation in migraine patients and Evoked Potential types: Analysis study from EEG signals

Abstract

Inability of habituation is a phenomenon whereby droop responses of cortical responses to repetitive sensory stimulation where the amplitude is persistently increased, which results in an increase in the stimulation time in migraineurs. In contrast, in healthy subjects, the cortical responses to repeated sensory stimuli become progressively lower with respect to the start of the stimulation. This abnormal responsivity to painful or painless stimuli, which becomes visible in the N2P2 in EEG rhythms with repeated stimuli, is a significant feature of migraine patients, so it plays an important role in classifying the phases of migraine (interictal, pre-ictal). The main role of genetics in migraine and its significance in the mechanisms is that it causes altered habits and abnormalities in cortical excitability in both adults and children who are closely related to parent and first-degree relative migraineurs[140-144]. Moreover, habituation and abnormality of cortical excitability increased during the period of hormones in a female who suffers from migraines. In this review, we have tried to outline and discuss the most important research findings over the past twenty years with regard to the habituation deficit in many aspects, such as migraine, its causes, and the role of EEG rhythms in the diagnosis and rehabilitation of migraine patients[144]. The findings of the review indicate that future research may need to create a new classification dependent on EEG recordings which can be used to distinguish between the two types of migraine: with aura (MWA) and without aura (MWoA)[144].