Abstract
To determine whether the development of hepatic Echinococcus multilocularis infection is influenced by major histocompatibility-linked genes, metacestode growth and host immune responses were compared in 4 C57BL 10 congenic murine strains of H-2 b, H-2 d, H-2 k and H-2 q haplotypes. Although the H-2 q strain appeared slightly more resistant than the other strains, the 4 strains of mice developed comparable spleen cell proliferative response and Th1 Th2 cytokine production at 13 weeks p.i. A kinetic analysis, performed in 2 of these congenic strains, showed a similar pattern of parasite growth in these mice and failed to detect any significant difference in the production of parasite-specific IgM, IgG 1 and IgG 2a antibodies. Consequently, this study indicates that the control of secondary alveolar echinococcosis is not H-2 gene-linked.
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