Lack of effect of quinidine on divalent mineral absorption from the reticulorumen of sheep

Abstract

The effects of quinidine on divalent mineral absorption were studied using normal and high potassium intraruminal buffers with the in vivo isolated washed rumen technique. A concentration of 1 mmol litre-1 quinidine in the intraruminal buffer decreased the absorption rates of Na + and Cl − from the rumen but had no significant effect on the absorption rates of Mg 2+, Ca 2+ and K +. Prolonged oral administration of quinidine had no significant effect on the absorption of any of these ions from either a normal or a high potassium ruminal solution.