Abstract
In mouse liver polyribosomes two poly A-containing messenger RNA species have been found: a short-lived one with a lifetime of 1 to 1.5 hr in the free polyribosomes and a more stable with a lifetime of 5 to 6 hr. When both species of the steady-state labeled mRNAs were examined for poly A size distribution, they showed sets of similar size (170A–70A), indicating no direct dependence upon the initial length of poly A and the lifetimes of the corresponding mRNAs. Poly A in both species of mRNA is actually shortened during the ‘cold’ and ‘actinomycin d chase’. From these results it was concluded that the rate of shortening of poly A, rather than its initial length, could control the mRNA stability.
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