Abstract
Hepatic microsomes were prepared from liver sections removed from anesthetised New Zealand White rabbits. Two groups of rabbits, distinguished by different levels of progesterone 21-hydroxylase, were compared for in vitro and in vivo metabolism of [ 3H]deoxycorticosterone/[ 14C]-progesterone mixtures. In vitro, microsomes with low 21-hydroxylase activity gave significantly lower yields of pregnenoic acid than those with higher 21-hydroxylase activities. In vivo, these differences were not evident from an examination of the 3H/ 14C ratios of acidic urinary metabolites.
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