Abstract
In burn-injured patients we have previously shown that skin has a decreased autoregulatory blood flow adjustment. Lack of such a function in skin would make uncontrolled use of vasoconstrictors detrimental to this organ. If ischemia-like conditions are produced in the skin, use could enhance the inflammatory response and increase the risk of organ dysfunction. We exposed local areas of the skin in healthy volunteers to therapeutic levels of noradrenaline (NA) by infusion through microdialysis (MD) intradermally, to investigate whether autoregulatory escape is present in the skin during strong α1-adrenergic stimulation.
Highlights
There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient’s experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients
The arterial catheterrelated infection (ACRI) incidence per 1,000 arterial catheter days was significantly higher for femoral (5.08) than for radial (1.76) access (OR = 5.1, 95% cardiac index (CI) = 2.56 to 10.81; P ≤0.001), dorsalis pedis (0) access (OR = 7.6; 95% CI = 1.37 to infinite; P = 0.01) and brachial (0) access (OR = 6.2, 95% CI = 1.11 to infinite; P = 0.03)
Results of this study show that early tracheostomy, if perioperative complications
Summary
There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient’s experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients. Conclusions Our data demonstrate that critically ill patients may be exposed to a higher FiO2 than that required to maintain adequate oxygenation These results highlight an area of ICU care that has received little study, with no published clinical trials examining the effect of FiO2 on outcome. Results Age, sex, the underlying disease and tumour stage (TNM classification), type of previous anticancer treatment, performance status, severity scores (APACHE II, Simplified Acute Physiology Score II, Sequential Organ Failure Assessment), ICU and hospital mortalities and hospital outcome at 3, 6 and 12 months were analysed. Clinical data of 277 post-transplantation patients admitted to the ICU were collected at admission and the SAPS 3 and APACHE II score calculated with respective estimated mortality rates.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
