Lack of association of the IL-1RN and IL-10 polymorphisms with risk of psoriasis: A meta-analysis.

Abstract

BackgroundThe present study carried out a meta‐analysis to investigate whether the interleukin‐1 receptor antagonist (IL‐1RN) VNTR polymorphism and three IL‐10 single‐nucleotide polymorphisms (SNPs) rs1800896, rs3021097, and rs1800872 are associated with psoriasis risk.MethodsWanfang, China National Knowledge Infrastructure, Medline, and PubMed databases were searched for potential studies published until 2 November 2017. Forest plots were generated.ResultsThirteen case–control studies were included in the review. The results of meta‐analyses revealed no association of the IL‐1RN*2 allele with psoriasis in the overall populations (odds ratio [OR] = 1.16, 95% confidence intervals [CI]: 0.89–1.50, p = 0.279), Asians (OR = 1.27, 95% CI: 0.73–2.23, p = 0.403), and Caucasians (OR = 1.04, 95% CI: 0.88–1.23, p = 0.669). Under the allelic model, there was no statistically significant association of psoriasis with the IL‐10 SNPs rs1800896 (G allele vs. A allele: OR = 1.03, 95% CI: 0.90–1.18, p = 0.639), rs3021097 (C allele vs. T allele: OR = 1.17, 95% CI: 0.88–1.56, p = 0.288), and rs1800872 (C allele vs. A allele: OR = 1.01, 95% CI: 0.81–1.25, p = 0.951). No publication bias was found by Egger's test and Begg's funnel plots.ConclusionCurrent published studies fail to support an association of the IL‐1RN VNTR polymorphism and IL‐10 SNPs rs1800896, rs3021097, and rs1800872 with psoriasis risk.