Abstract
Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis. A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and I2 statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis. Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively. In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.
Highlights
Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies that originates in the lymphatic organs (Zelenetz et al, 2010; Sangrajrang et al, 2011; Amanat et al, 2013)
Literature search A total of 7 published articles regarding the relationship between taking Aspirin, and NHL the NHL were identified by applying the inclusion criteria (Figure 1) and 3 articles reported intake red meat and risk subtype NHL(Erber et al, 2009; Teras et al; Baker et al, 2005)
According to analysis of subgroups, a statistically significant difference was observed in the effect of taking aspirin in women suffered from NHL
Summary
Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies that originates in the lymphatic organs (Zelenetz et al, 2010; Sangrajrang et al, 2011; Amanat et al, 2013). NHL is the seventh most common cancer and the sixth leading cause of death from cancer in USA (Hernandez et al, 2010; Amoori et al.,2014) Mortality rate of this type of cancer has substantially increased (Clarke et al, 2002; Zekri et al, 2013) in developed countries as well as developing countries and will double every 20 years (Devesa et al, 1992; Broccia et al, 2001) It more occurs because of malfunction of immune system, including primary immunodeficiency syndromes, immunosuppressive drugs for transplant patients, and the immunodeficiency human virus (HIV) (Ansell et al, 2005; Yildirim et al, 2013). We performed a meta-analysis study to evaluate the potential relationship between using aspirin and the development of NHL. Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis. Conclusions: In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma
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