Abstract
An increasing number of studies have shown that an inflammatory process is part of Parkinson's disease (PD) brain pathology. Interleukin-1 (IL-1) is a multifunctional cytokine and is considered to contribute to several inflammatory diseases. Recently, we detected an associated risk in a subgroup of PD patients with a disease onset <50 years and a C to T transition in the IL-1α promoter (−889). One-hundred-seventy-six German PD patients (42.1±6.4 years; 42.4% male) and 170 unrelated age-matched control individuals (40.4±8.7 years; 57.6% male) were investigated for the presence of the IL-1α (−889C/T) polymorphism. No significant difference in the allelic distribution of the analyzed IL-1α polymorphism has been found between PD and controls. We conclude that the C/T polymorphism in the IL-1α promoter region at −889 does not increase the risk to develop PD.
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