Abstract
Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI: 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI: 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.
Highlights
Atherosclerosis underlies the leading cause of death in industrialized societies and is likely soon to attain this status worldwide (Lloyd-Jones et al, 2010)
Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques
The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction
Summary
Atherosclerosis underlies the leading cause of death in industrialized societies and is likely soon to attain this status worldwide (Lloyd-Jones et al, 2010). When coronary artery disease develops, vessels will be obstructed which cause acute coronary syndrome (ACS) (Shea et al, 1984; Thom et al, 2006). ACS has an abrupt onset and presents with a severe chest pain or other equivalent symptoms. ACS divides into three types based on changes in electrocardiogram (ECG) includes unstable angina and non-ST elevation myocardial infarction which have no change in ECG and ST-elevation myocardial infarction that presents with elevation in ST segment of ECG (Khosravi et al, 2008). Underlying pathology which causes ACS is atherosclerotic plaques that lead to failure of blood supply in coronary arteries. Genetics and environmental factors are important ones such as family history, obesity, hyperlipidemia, diabetes mellitus, inflammation and hypertension (Shea et al, 1984; Godfrey et al, 1994; Thom et al, 2006; Shojaie et al, 2009; Shojaie et al, 2009; Jahromi et al, 2013; Jahromi et al, 2014)
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