Abstract
Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.
Highlights
Worldwide, breast cancer (BC) is the most common invasive cancer in women
А meta-analysis of 37 studies of rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 polymorphisms demonstrated that these Fibroblast growth factor receptor 2 (FGFR2) Single Nucleotide Polymorphism (SNP) are a risk factor associated with increased BC susceptibility, but these associations vary significantly in different racial and ethnic groups [4]
The aim of the present work was to determine the association of individual SNPs in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 sites of FGFR2 with BC in Kazakh and Russian ethnic groups of Kazakhstan
Summary
Breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and overexpressed in breast cancer [1]-[3]. А meta-analysis of 37 studies of rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 polymorphisms demonstrated that these FGFR2 SNPs are a risk factor associated with increased BC susceptibility, but these associations vary significantly in different racial and ethnic groups [4]. Significant associations between breast cancer risk and SNPs in rs11200014, rs2981579, rs1219648, rs2420946 of FGFR2 (Ptrend for all SNPs < 0.0001) were found in Jewish and Arab Israeli population [5]. The multinational population of Kazakhstan totaled 17.2 million in 2013 with the major ethnic groups represented by mongoloid Asian Kazakhs (65%) and Caucasian Russians (22%), according to the Agency of the Republic of Kazakhstan on Statistics data [6]
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