Abstract
The relation between plasma-renin activity and the occurrence of heart-attacks and strokes was examined in 371 Black patients with essential hypertension, who were categorised as having low, normal, or high renin activity according to their 24-hour sodium excretion. The incidence of such complications was found to be identical in each of the renin subgroups. No evidence was found to support the proposal that patients with low renin hypertension are protected against these complications, or that high renin activity is vasculotoxic per se. These findings are not consistent with the view that plasma-renin activity is a potential risk factor in uncomplicated essential hypertension, and emphasise the need for effective therapy in all hypertensive patients regardless of the plasma-renin activity.
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