Abstract
BackgroundThe association between NAD(P)H:quinone oxidoreductase 1 (NQO1) gene C609T polymorphism (rs1800566) and lung cancer has been widely evaluated, and a definitive answer so far is lacking. We first conducted a case-control study to assess this association in northeastern Han Chinese, and then performed a meta-analysis to further address this issue.Methodology/Principal FindingsThis case-control study involved 684 patients clinically diagnosed as lung cancer and 602 age-matched cancer-free controls from Harbin city, Heilongjiang province, China. Genotyping was conducted using the PCR-LDR (ligase detection reactions) method. Meta-analysis was managed by STATA software. Data and study quality were assessed in duplicate. Our case-control association study indicated no significant difference in the genotype and allele distributions of C609T polymorphism between lung cancer patients and controls, consistent with the results of the further meta-analysis involving 7286 patients and 9167 controls under both allelic (odds ratio (OR) = 0.99; 95% confidence interval (CI): 0.92–1.06; P = 0.692) and dominant (OR = 0.98; 95% CI: 0.89–1.08; P = 0.637) models. However, there was moderate evidence of between-study heterogeneity and low probability of publication bias. Further subgroup analyses by ethnicity, source of controls and sample size detected no positive associations in this meta-analysis.ConclusionsOur study in northeastern Han Chinese, along with the meta-analysis, failed to confirm the association of NQO1 gene C609T polymorphism with lung cancer risk, even across different ethnic populations.
Highlights
Lung cancer is one of the common malignancies, and nearly 1.3 million new cases are diagnosed annually worldwide [1,2]
Evidence is mounting suggesting that the cause of lung cancer is multifactorial, and part is due to genetic defects
Among all lung cancer patients, the subtype of adenocarcinoma, squamous cell cancer, small cell cancer, and unspecified cancer accounted for 37.54%, 32.26%, 20.83%, and 9.38%, respectively
Summary
Lung cancer is one of the common malignancies, and nearly 1.3 million new cases are diagnosed annually worldwide [1,2]. Evidence is mounting suggesting that the cause of lung cancer is multifactorial, and part is due to genetic defects. The gene encoding NAD(P)H:quinone oxidoreductase 1 (NQO1) is a promising candidate in the pathogenesis of lung cancer [3,4]. In tissues of human lung cancer, NQO1 gene was observed to be over-expressed [5,7,8,9]. It is of added interest to identity genetic defects of NQO1 gene responsible for its enzyme activity, further accountable for lung carcinogenesis. The association between NAD(P)H:quinone oxidoreductase 1 (NQO1) gene C609T polymorphism (rs1800566) and lung cancer has been widely evaluated, and a definitive answer so far is lacking.
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