Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese

Abstract

Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for schizophrenia. Hoping to validate this finding, we conducted a case–control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls, using the LDR-PCR method to genotype polymorphisms (rs10489202 and a TagSNP rs203861) in the MPC2 gene. However, we found no significant difference (P>0.05) in either allele or genotype frequency in the SNPs between patients and controls. These results did not support the previous finding suggesting the further study by using a large-scale association analysis in the future should be warranted in Han Chinese populations.