Lack of association between mitochondrial DNA polymorphisms and didexoxynucleoside-induced hyperlactataemia in black-African, HIV-1-infected patients

A Arenas-Pinto,N Bradman,I Weller,S Charalambous,R Ekong,C Ingram,A Grant,M Bolhaar,A Karstaedt,L Telisinghe

doi:10.1186/1758-2652-13-s4-p96

Abstract

Background: Recent studies have shown some association between specific mitochondrial DNA (mtDNA) polymorphisms and peripheral neuropathy in both white European and black American populations. An association between mtDNA haplogroup H and peripheral lipoatrophy has been reported in white Europeans. Our group has shown a lack of association between mtDNA polymorphisms and the occurrence of HL in white Europeans exposed to dideoxynucleosides, but there have been no studies in black African people. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug Therapy in HIV Infection 7-11 November 2010 Glasgow, UK (Published: 8 November 2010) doi:10.1186/1758-2652-13-S4-P96 Cite this article as: Arenas-Pinto et al.: Lack of association between mitochondrial DNA polymorphisms and didexoxynucleoside-induced hyperlactataemia in black-African, HIV-1-infected patients. Journal of the International AIDS Society 2010 13(Suppl 4):P96. Full text: PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113104/

Highlights

Recent studies have shown some association between specific mitochondrial DNA polymorphisms and peripheral neuropathy in both white European and black American populations
Our group has shown a lack of association between mitochondrial DNA (mtDNA) polymorphisms and the occurrence of HL in white Europeans exposed to dideoxynucleosides, but there have been no studies in black African people
Methods mtDNA was extracted from oral mucosa epithelial cells from HIV1-infected active patients seen at Chris Hani Baragwanath Hospital in Johannesburg, South Africa

Summary

Introduction

Lack of association between mitochondrial DNA polymorphisms and didexoxynucleosideinduced hyperlactataemia in black-African, HIV-1-infected patients Background Recent studies have shown some association between specific mitochondrial DNA (mtDNA) polymorphisms and peripheral neuropathy in both white European and black American populations. An association between mtDNA haplogroup H and peripheral lipoatrophy has been reported in white Europeans. Our group has shown a lack of association between mtDNA polymorphisms and the occurrence of HL in white Europeans exposed to dideoxynucleosides, but there have been no studies in black African people.

Results

Conclusion