Abstract
Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case–control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case–control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P=0.465; GG vs. CC: adjusted P=0.436, CG/GG vs. CC: adjusted P=0.387 and GG vs. CC/CG: adjusted P=0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P=0.537; GG vs. CC: P=0.517, CG/GG vs. CC: P=0.520 and GG vs. CC/CG: P=0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case–control studies are needed to confirm our results.
Highlights
In 2018, it was reported that over 1.8 million new colorectal cancer (CRC) cases were diagnosed and 881,000 CRC-related deaths occurred worldwide [1]
Data of genotypes and environmental factors are summarized in Supplementary Table S1
We found that there were no significant association between miR-146a rs2910164 polymorphism and susceptibility of
Summary
In 2018, it was reported that over 1.8 million new colorectal cancer (CRC) cases were diagnosed and 881,000 CRC-related deaths occurred worldwide [1]. In China, CRC ranked both fifth in terms of malignancy incidence and mortality [2]. Trend of cancer incidence indicated that a significant upward trend was found for CRC in developing countries [3]. Previous studies attributed CRC to aging, unhealthy lifestyle and environmental factors [4–7]. It should be very important to understand susceptibility factors of CRC as they could be beneficial for the evaluation of prevention strategies and susceptibility. Accumulating evidences have shown that an individual’s inherited factors contribute to the development of CRC
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
