Abstract
BackgroundElevated lipoprotein(a) [Lp(a)] levels predict cardiovascular events incidence in patients with coronary artery disease (CAD). Genetic variants in the rs3798220, rs10455872 and rs6415084 single-nucleotide polymorphisms (SNPs) in the Lp(a) gene (LPA) correlate with elevated Lp(a) levels, but whether these SNPs have prognostic value for CAD patients is unknown. The present study evaluated the association of LPA SNPs with incidence of subsequent cardiovascular events in CAD patients after percutaneous coronary intervention (PCI).MethodsTaqMan SNP genotyping assays were performed to detect the rs6415084, rs3798220 and rs10455872 genotypes in 517 Chinese Han patients with CAD after PCI. We later assessed whether there was an association of these SNPs with incidence of major adverse cardiovascular events (MACE: cardiac death, nonfatal myocardial infarction, ischemic stroke and coronary revascularization). Serum lipid profiles were also determined using biochemical methods.ResultsOnly the rs6415084 variant allele was associated with higher Lp(a) levels [41.3 (20.8, 74.6) vs. 18.6 (10.3, 40.9) mg/dl, p < 0.001]. During a 2-year follow-up period, 102 patients suffered MACE, and Cox regression analysis demonstrated that elevated Lp(a) (≥30 mg/dl) levels correlated with increased MACE (adjusted HR, 1.69; 95% CI 1.13-2.53), but there was no association between LPA genetic variants (rs6415084 and rs3798220) and MACE incidence (p > 0.05).ConclusionsOur data did not support a relationship between genetic LPA variants (rs6415084 and rs3798220) and subsequent cardiovascular events after PCI in Chinese Han CAD patients.
Highlights
Cardiovascular disease is the leading cause of morbidity and mortality worldwide
Lp(a) is a plasma lipoprotein consisting of a cholesterolrich low density lipoprotein (LDL) particle with one apolipoprotein B100 molecule and an additional apolipoprotein(a) (apo(a)) protein attached via a disulfide bond [1]
Of the three single-nucleotide polymorphisms (SNPs) studied, both rs6415084 and rs3798220 were prevalent in our cohort except rs10455872, for which the variant allele was present in only two patients (G)
Summary
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In past decades, multiple cardiovascular disease risk factors have been identified and used for risk stratification and outcome evaluations; lipoprotein (a) (Lp(a)) is one of the most attractive and promising risk factors.Lp(a) is a plasma lipoprotein consisting of a cholesterolrich low density lipoprotein (LDL) particle with one apolipoprotein B100 (apoB100) molecule and an additional apolipoprotein(a) (apo(a)) protein attached via a disulfide bond [1]. A series of case–control studies demonstrated that rs10455872 and rs3798220 are significantly associated with CAD and myocardial infarction risk and are associated with atherosclerotic burden, obstructed coronary artery number and an earlier CAD diagnosis [17,18,19] Whether these two LPA SNPs correlate to subsequent cardiovascular event risk for CAD patients after PCI is unknown. The present study was aimed to explore the association between the two aforementioned SNPs in addition to another LPA SNP rs6415084, which is a short variation in the 5’ haplotype block of LPA and correlates with Lp(a) levels [12], and the incidence of subsequent cardiovascular events in Chinese Han patients with CAD after PCI. The present study evaluated the association of LPA SNPs with incidence of subsequent cardiovascular events in CAD patients after percutaneous coronary intervention (PCI)
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