Abstract
BackgroundInterleukin-10 (IL-10) is an important immunomodulatory cytokine. Several studies focused the association between IL-10 promoter gene polymorphisms and graft rejection risk in kidney transplantation recipients. However, the results of these studies remain inconclusive. The aim of this study was to conduct a meta-analysis to further assess the associations.MethodsThe PubMed, Embase, and Ovid Medline databases were searched. Two independent authors extracted data, and the effects were estimated from an odds ratio (OR) with 95% confidence intervals (CIs). Subgroup and sensitivity analyses identified sources of heterogeneity.ResultsA total of 16 studies including 595 rejection patients and 1239 stable graft patients were included in order to study the IL-10 -1082 (rs1800896 G/A), -819 (rs1800871 C/T), -592 (rs1800872 C/A) and IL-10 (-1082,-819,-592) polymorphisms. The -1082 G/A polymorphism was not associated with an increased graft rejection risk (OR = 1.03; 95%CI, 0.85–1.25, P = 0.74 for GA+AA vs. GG model). Moreover, all of the -819 C/T (OR = 1.06, 95%CI, 0.79–1.42, P = 0.70 for TA+TT vs. CC model), -592 C/A (OR = 1.10, 95% CI, 0.85–1.42, P = 0.47 for AC+AA vs. CC model) and IL-10 (-1082,-819,-592) polymorphisms (OR = 1.00, 95%CI, 0.79–1.27, P = 0.98 for I+L vs. H model) did not increase the graft rejection risk. In addition, we also performed subgroup analysis by ethnic group (mainly in Europeans or Asians) and rejection type (acute or chronic). There was also lack of evidence of a significant association between the IL-10 gene polymorphism and graft rejection risk. The present meta-analysis indicated that the IL-10 gene polymorphism was not associated with graft rejection risk in kidney transplantation recipients.ConclusionThis meta-analysis found evidence that the IL-10 polymorphism does not increase the risk of graft rejection in kidney transplantation recipients. Further chronic rejection and other ethnic population studies are needed to confirm our results.
Highlights
Worldwide, kidney transplantation (KTx) is recognized as a treatment for end-stage renal disease (ESRD) [1]
The -1082 G/A polymorphism was not associated with an increased graft rejection risk (OR = 1.03; 95%confidence intervals (CIs), 0.85–1.25, P = 0.74 for GA+AA vs. GG model)
Association between IL-10 Gene Polymorphisms and Graft Rejection Risk indicated that the IL-10 gene polymorphism was not associated with graft rejection risk in kidney transplantation recipients. This meta-analysis found evidence that the IL-10 polymorphism does not increase the risk of graft rejection in kidney transplantation recipients
Summary
Kidney transplantation (KTx) is recognized as a treatment for end-stage renal disease (ESRD) [1]. It provides a better quality and quantity of life than dialysis treatments for its cost effectiveness [2]. Patient survival for those who received a kidney transplant has progressively improved towards 90%, and 1-year graft survival for deceased donor kidney transplantation has increased to 91% in Europeans [3]. Acute rejection may result in graft loss, increased risk of chronic allograft dysfunction, and poor long-term outcomes [5]. Delayed graft function predisposes patients to worse long-term outcomes by increasing the risk for acute rejection and subsequent chronic allograft dysfunction [6]. The aim of this study was to conduct a meta-analysis to further assess the associations
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