Lack of Association between Impulse Control Disorders and REM Sleep Behavior Disorder in Patients with Parkinson’s Disease

Lisette Bazán-Rodríguez,Francisco Pascasio-Astudillo,Mayela Rodríguez-Violante,Diego Cruz-Fino,Vanessa Alatriste-Booth,Guillermo Parra-López,Amin Cervantes-Arriaga

doi:10.4236/apd.2016.54009

Lisette Bazán-Rodríguez, Francisco Pascasio-Astudillo + Show 5 more

Open Access

https://doi.org/10.4236/apd.2016.54009

Copy DOI

Abstract

Purpose: Rapid eye movement sleep behavior disorder (RBD) and impulse control disorders (ICDs) are common in subjects with Parkinson’s disease. The association between these two conditions has been contradictory. The aim of this study is to analyze the association between these two non-motor symptoms. Methods: Consecutive subjects with Parkinson’s disease attending the Movement Disorders Outpatient Clinic were included. The presence of ICDs was assessed using the Questionnaire for Impulse Control Disorders Rating Scale. RBD was diagnosed by an overnight, single night polysomnography. Results: Fifty-five consecutive subjects with Parkinson’s disease were included. The prevalence of ICDs and related behaviors was 23.6% (ICD in 14.5% and related behaviors in 9.1%). RBD was diagnosed in 47.2% of the patients. No differences were found in the frequency of ICDs and related behaviors when comparing subjects with and without RBD (23% versus 24.1%, p = 0.926, respectively). Conclusion: No association between the presence of RBD and the frequency of ICDs in subjects with Parkinson’s disease was found.

Highlights

No differences were found in the frequency of impulse control disorders (ICDs) and related behaviors when comparing subjects with and without Rapid eye movement sleep behavior disorder (RBD) (23% versus 24.1%, p = 0.926, respectively)
The prevalence of ICDs has been reported to be of 13.6% [2], but in patients treated with dopamine agonists (DA) the frequency can be as high as 24% [3]
The objective of our study is to analyze the association between RBD confirmed by polysomnography (PSG) and ICD diagnosed with a validated questionnaire in patients with PD

Summary

Introduction

Impulse control disorders (ICDs) and rapid eye movement sleep behavior disorder (RBD) are two well-known non-motor symptoms associated with Parkinson’s disease. The prevalence of ICDs has been reported to be of 13.6% [2], but in patients treated with dopamine agonists (DA) the frequency can be as high as 24% [3]. Predisposing factors for ICDs in PD include the use of high doses of DA, a younger age, male gender, an early onset of motor symptoms, depression, a personal history of addictive behaviors, as well as genetic factors [4]. Prevalence of RBD in subjects with PD has been reported to be between 15% and 47% depending on the assessment method [5]. ; these patients appear to have an increased risk for cognitive decline and dementia [7]

Objectives

Methods

Conclusion