Abstract
It has been proposed that genetic factors account for 30%–50% of the risk for cocaine and heroin addiction. The present study was aimed to find out the impact of µ-opioid receptor gene ( OPRM1 ) rs1799971 A > G and rs9479757 polymorphisms on heroin dependence in a sample of southeast Iranian population. This case-control study was done on 123 heroin addicts and 140 non-addicts Iranian male. Genomic DNA was extracted from peripheral blood cells using salting out method. Genotyping of OPRM1 rs1799971 and rs9479757 polymorphisms were performed using PCR-RFLP method. Overall, our results did not support an association between OPRM1 variants and risk of heroin dependence in a sample of southeast Iranian population. Further studies with larges sample sizes and different ethnicities are required to validate our findings.
Highlights
Opioid abuse is an important major social and economic problem worldwide
The findings proposed that this variant was not associated with heroin dependence
We examined the impact of OPRM1 rs1799971 (A118G, Asn40ASp) and rs9479757 polymorphisms on heroin dependence in a sample of southeast Iranian population
Summary
Opioid abuse is an important major social and economic problem worldwide. The annual global prevalence of opioid abuse was estimated at between 28 and 38 million users [1]. Physiological dependence is one of the key features that maintain repeated opioid use, contributing significantly to the cycle of chronic use/abuse [2]. It has been proposed that genetic and environmental factors contribution to individual differences in vulnerability to drug addictions. Heroin addiction is a chronic disease characterized by compulsive drug seeking, drug abuse, tolerance and physical dependence. Twin studies have proposed that genetic factors account for nearly 30%–60% of the overall variance in the risk of developing drug addiction [3,4,5]
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