Abstract

Aim: To investigate the relation between polymorphisms in the interleukin 10 (IL)-10, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β and interferon (IFN)-γ genes and Takayasu’s arteritis in the Mexican population. Methods: A case-control study was performed to investigate the associations of IL-10, TNF-α, TGF-β and IFN-γ polymorphisms in a sample of 52 Takayasu’s arteritis patients, diagnosed according to the criteria of the American College of Rheumatology and EULAR PRINTO criteria when the patients were under 18 years of age; 60 clinically healthy unrelated Mexican individuals by the 5′ exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. Results: Significant differences were not found in the distribution for genotype and allele frequencies of the polymorphisms studied between healthy controls and Takayasu´s arteritis patients. Likewise, significant associations were not detected in the haplotype analysis with the different genes studied. Conclusions: These findings suggest that the polymorphisms in IL-10, TNF-α, TGF-β and IFN-γ might not contribute to the susceptibility of Takayasu´s arteritis in the Mexican population.

Highlights

  • Takayasu0 s arteritis (TA) is an inflammatory disease that affects medium and large arteries, predominantly the aorta and its main branches

  • Inflammation in Takayasus arteritis begins around the vasa vasorum and it is accompanied by the infiltration of several inflammatory cells, leading to granuloma formation

  • A total of 112 subjects were analyzed, including 52 Takayasus arteritis patients according to the American College of Rheumatology criteria

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Summary

Introduction

Takayasu0 s arteritis (TA) is an inflammatory disease that affects medium and large arteries, predominantly the aorta and its main branches. The clinical manifestations of Takayasus arteritis usually appear in childbearing-age women [1,2]. Inflammation in Takayasus arteritis begins around the vasa vasorum and it is accompanied by the infiltration of several inflammatory cells, leading to granuloma formation. At this stage, the production of inflammatory mediators is markedly increased [3,4]. The production of inflammatory mediators is markedly increased [3,4] This response includes many factors such as

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