Abstract
Method We search the PubMed, Embase, Google Scholar, and Wanfang (China) databases (up to December 1, 2020) to identify all eligible publications. The pooled odds ratio (OR) correspondence with 95% confidence interval (CI) was calculated to evaluate the associations. Results Finally, nine eligible studies with 7,157 cases and 6,440 controls and five studies with 2,278 cases and 2,821 controls were enrolled in rs3877899 and rs7579 polymorphisms, individually. However, a null significant association was detected between the two polymorphisms in SEPP1 and susceptibility to colorectal, breast, and prostate cancer in all comparison models. Subsequently, subgroup analysis based on tumor type, no significant association was identified for prostate, breast, and colorectal cancer. In addition, when the stratification analyses were conducted by the source of control, HWE status, and ethnicity, yet no significant association was found. Conclusions The current meta-analysis shows that SEPP1 rs3877899 and rs7579 polymorphisms may not be associated with susceptibility to colon cancer, breast cancer, and prostate cancer, and further well-designed studies with a larger sample size are warranted to validate our findings.
Highlights
There has been a progressive increase in the global incidence of malignancies, causing a serious threat to human health, presently, among the main causes of death [1]
A comprehensively retrieve of the literature concerning relationships between the SEPP1 polymorphisms and cancer susceptibility was performed on PubMed, Embase, and Google Scholar databases by using the following searching terms: “SEPP1 odds ratio (OR) Selenoprotein P” AND “polymorphism OR variation OR SNP OR genotype OR allele OR mutation” AND “cancer OR malignancy OR tumor OR neoplasm OR carcinoma”
Included literature should be in line with the following criteria: (1) studies that evaluated the relationship between SEPP1 polymorphisms and cancer susceptibility; (2) sufficient genotype data from the text or the supporting information; (3) case-control studies
Summary
There has been a progressive increase in the global incidence of malignancies, causing a serious threat to human health, presently, among the main causes of death [1]. Studies concerning SEPP1 gene polymorphisms and cancer susceptibility have been extensively investigated, whereas results from these studies remain debatable rather than conclusive. We performed the present meta-analysis to comprehensively assess the association between two common polymorphisms (rs3877899 and rs7579) in SEPP1 and cancer susceptibility. A null significant association was detected between the two polymorphisms in SEPP1 and susceptibility to colorectal, breast, and prostate cancer in all comparison models. Subgroup analysis based on tumor type, no significant association was identified for prostate, breast, and colorectal cancer. The current meta-analysis shows that SEPP1 rs3877899 and rs7579 polymorphisms may not be associated with susceptibility to colon cancer, breast cancer, and prostate cancer, and further well-designed studies with a larger sample size are warranted to validate our findings
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