Abstract
Lack of association between CDKN2A germline mutations and survival in patients with melanoma: A retrospective cohort study
Highlights
Our finding that CDKN2A mutation status is not associated with worse OS or RFS is in line with that of an Italian cohort study.5 In contrast, 2 Swedish studies showed worse survival for CDKN2A-mut patients.3,4 The aims and design of the studies differed
CDKN2A-mut patients more often developed multiple primary melanomas (MPMs) than patients with sporadic melanoma (42.7% vs 4.0%; P \.0001)
IRB approval status: Ethical approval was granted by the ethical review boards of PALGA, Houten, the Netherlands, and Leiden University Medical Center
Summary
Our finding that CDKN2A mutation status is not associated with worse OS or RFS is in line with that of an Italian cohort study.5 In contrast, 2 Swedish studies showed worse survival for CDKN2A-mut patients.3,4 The aims and design of the studies differed. MD, PhD,a and the Netherlands Foundation for Detection of Hereditary Tumors collaborative investigators* Median age at diagnosis of first melanoma, y (IQR) Year of diagnosis 2000/2001 2002/2003 2004/2005 2006/2007 2008/2009 2010/2011 2012/2013/2014
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