Lack of association between 4-base pair insertion/deletion (rs3783553) polymorphism within the 3′UTR of IL1A and breast cancer: A preliminary report

Abstract

As a complex disease, various factors are implicated in breast cancer (BC) etiopathogenesis. Mounting evidence indicating that cytokines are one of the crucial elements of carcinogenesis. Interleukin (IL)-1a is a key regulatory cytokine involved in inflammation, immune system activities, and several human diseases, including BC. Eventually, polymorphisms of the IL1A gene can alter IL-1a expression and function. The present study explored the possible relationship between rs3783553as a functional polymorphism in the 3′ untranslated region of IL1A and BC risk. This case-control study was completed on 190 BC patients and 200 age-matched healthy female subjects. Genotyping for rs3783553 was done by mismatched polymerase chain reaction-restriction fragment length polymorphism. The results showed that rs3783553 was not associated with BC risk in any hereditary models (OR = 0.75, 95%CI = 0.50–1.13, p = 0.18, ins/del vs ins/ins and OR = 0.92, 95%CI = 0.29–2.95, p = 0.99, del/del vs ins/ins for codominant; OR = 0.77, 95%CI = 0.51–1.14, p = 0.22, ins/del + del/del vs ins/ins for dominant; OR = 1.05, 95%CI = 0.33–3.32, p = 0.99, del/del vs ins/ins + ins/del for recessive) as well as allele frequency (OR = 0.85, 95%CI = 0.62–1.16, p = 0.33, del vs ins). Our finding indicated the lack of association between rs3783553 and susceptibility to BC in a sample from southeast of Iran. Further studies in other ethnic groups with a larger study population should be done to elucidate the exact association of rs3783553 and BC susceptibility.