Abstract
Department of Obstetrics and Gynecology, and Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02115, U.S.A. (Received 19 May 1975) Testosterone and its ring A reduced metabolite, dihydrotestosterone (DHT), lower gonadotrophin concentrations in weaned rats (Swerdloff, Walsh & Odell, 1972; Naftolin & Feder, 1973). While neonatally administered testosterone causes anovulatory sterility in adult female rats, similar treatment with DHT has no apparent effect upon central neuroendocrine programming (Brown-Grant, Munck, Naftolin & Sherwood, 1971; Whalen & Luttge, 1971), which raises the question of whether DHT can suppress gonadotrophins in the neonatal rat. In the first experiment, 5-day-old Sprague–Dawley-derived rats (Charles River Farms) were injected s.c. with 100 μg DHT propionate (DHTP), 100 μg testosterone propionate (TP, Eli Lilly & Co.) or the sesame oil diluent, and allowed to develop without further treatment. The injection volume was 25 μl. All animals were weaned on day 20. Daily vaginal
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