Abstract
The aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy restricted group and a group submitted to energy restriction and treated with resveratrol. We measured liver triacylglycerols, transaminases, FAS, MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation. Resveratrol reduced triacylglycerols compared with the controls, although this reduction was lower than that induced by energy restriction. The mechanisms of action were different. Both decreased protein expression of fatty acid transporters, thus suggesting reduced fatty acid uptake from blood stream and liver triacylglycerol delivery, but only energy restriction reduced the assembly. These results show that resveratrol is useful for liver steatosis treatment within a balanced diet, although its effectiveness is lower than that of energy restriction. However, resveratrol is unable to increase the reduction in triacylglycerol content induced by energy restriction.
Highlights
Excessive fat accumulation in the liver is known as simple hepatic steatosis, which is the most benign form of non-alcoholic fatty liver disease (NAFLD)
Taking all of the information above into account, the aims of the present study were (a) to analyze the effect of resveratrol on liver steatosis previously induced by a high-fat high-sucrose diet in obese rats; (b) to compare the effects induced by resveratrol and energy restriction and (c) to research potential additive effects between resveratrol and energy restriction
The remaining animals fed the high-fat high-sucrose diet for six weeks were randomly divided into four experimental groups (n = 9): the control group (C), the resveratrol group treated with resveratrol (RSV), the restricted group submitted to a moderate energy restriction (R), and the group both treated with resveratrol as well as submitted to energy restriction (RR)
Summary
Excessive fat accumulation in the liver is known as simple hepatic steatosis, which is the most benign form of non-alcoholic fatty liver disease (NAFLD). It is a major cause of chronic liver disease in western societies, and this burden is expected to grow with the increasing incidence of obesity and metabolic syndrome, which are both closely associated with it [1,2]. Energy restriction is a commonly used method for fatty liver treatment [3,4] This method has been proved to induce a decrease in intrahepatic fat content in overweight and obese subjects [5,6]. Numerous studies have been carried out using resveratrol and different models of liver
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