LabPET II, a novel 64-channel APD-based PET detector module with individual pixel readout achieving submillimetric spatial resolution

Abstract

A new avalanche photodiode (APD) detector module, the LabPET II, was developed to achieve submillimetre spatial resolution for small animal molecular imaging. The module consists of two monolithic APD arrays of 4 × 8 pixels, each with an active area of 1.1 × 1.1 mm2 at a 1.2 mm pitch. The two APD arrays are mounted in a custom ceramic holder and coupled to an 8 × 8 LYSO scintillator array designed to accommodate one-to-one coupling between individual APDs and crystal pixels. An analog test board adapted from the LabPET™ processing electronics and consisting of four 16-channel preamplifier ASICs, was designed for testing the LabPET II detector module. The devices have a broad operating range (over 200 V) with breakdown voltage of ∼350 V, at which a typical gain well above 200 is reached. Individual APD pixels have a capacitance of 3.7 ± 0.4 pF (including stray capacitance), a typical dark current of 30 ± 11 nA, a dark noise of 0.13 ± 0.03 pA/Hz½ and an equivalent noise charge (ENC) of 12 e− rms at a gain of 100. At a standard APD operating bias, a mean energy resolution of 27.5 ± 2.1% was typically obtained with a relative standard deviation of 13.8% in signal amplitude for the 64 individual pixels when irradiated with 511 keV photons. A global timing resolution of 5.0 ± 0.2 ns FWHM was measured with two modules in coincidence. Finally, an intrinsic spatial resolution of 0.82 ± 0.02 mm FWHM (1.54 ± 0.05 mm FWTM) was obtained by sweeping a 22Na point source between two rows of the detector array. By deconvolving the source size and non-collinearity, an expected 0.73 mm intrinsic geometric crystal resolution is obtained. The LabPET II detector module is demonstrating promising characteristics for dedicated small animal PET imaging at submillimetre resolution and, with some further optimization, would be suitable as the building block for a dual-modality combined PET/CT system.