Laboratory testing of film-forming substances for the manufacture of ophthalmic medicinal films

Abstract

In the manufacture of ophthalmic medicinal films, special attention should be paid to the choice of a film-forming substance, since both the shape of the future film and its medicinal properties as a whole depend on it. This article provides a laboratory analysis with a comparative assessment of the optimal concentrations of two film-forming substances, polyvinyl alcohol and gelatin. Most of the presented film formers have a number of disadvantages, such as thickness, insufficient strength and elasticity, heterogeneity, formation of cracks and creases. One of the requirements for ophthalmic medicinal films is the smoothness of the surface and the absence of sharp corners. Based on the foregoing, we set the goal of the study - to conduct a laboratory test of film-forming substances for the manufacture of ophthalmic medicinal films. An analysis of domestic and foreign works gave reason to use polyvinyl alcohol and gelatin as the basis for ophthalmic medicinal films. As a result of the study, we have established the optimal concentrations of film-forming substances (polyvinyl alcohol and gelatin) that meet the existing requirements. The optimal concentration of the gelatin solution was the ratio of 1:7. The addition of the plasticizer glycerol to gelatinin the manufacture of ophthalmic medicinal films is mandatory. The optimal concentration of the solution of polyvinyl alcohol was the ratio of 1:15. Films from both film formers did not lose their shape, did not form cracks or breaks when introduced into the conjunctival sac. No irritant effect was observed. Laying the films did not cause difficulties. Forms of gelatin completely dissolved in the eye in 40 minutes, of polyvinyl alcohol - in 90 minutes.