Abstract
Clinical situations in which folate deficiency should be suspected and clinical evidence of folate deficiency are described. Laboratory tests used to assess folate status are primarily based on the developing sequence of events in the peripheral blood and bone marrow, and include determinations of serum folate, neutrophil hypersegmentation, urinary excretion of metabolites, erythrocyte folate, macrocytosis, and megaloblastic changes in bone marrow. The deoxyuridine suppression test is especially valuable in defining the presence of megaloblastosis and in differentiating between folate and vitamin B12 deficiencies.
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