Laboratory animal allergy: a new world.

Abstract

In recent years there has been a dramatic shift in the world of animal research whereby genetically modified mice have largely supplanted rats, and individually ventilated cages have been introduced to house delicate experimental animals in place of traditional open cages. Although laboratory animal allergy remains an important cause of occupational asthma, the risks associated with contemporary practice and consequently the opportunities for primary and secondary prevention are largely unknown. Although there is clear confirmation of a widespread increase in animal experiments using mice, the evidence-base on the associated risks has lagged. Individually ventilated cages reduce ambient levels of mouse urinary protein in air but task-based exposures are unquantified. Immunological techniques to identify sensitization to mouse proteins are poorly standardized. The available evidence suggests that modern practices are, in most cases, associated with a reduced incidence of animal sensitization. There is a paucity of data to inform evidence-based practice in methods to control the incidence of laboratory animal allergy under the prevailing research environment; a better understanding of the relationship between exposures and outcome is urgently needed. As exposures decline, the relative importance of individual susceptibility will become prominent.