Abstract
Contact photosensitization to certain plant materials, chemicals, and drugs has been known for a long time. Attention in recent years has been drawn to acceptable topical antibacterial agents employed in soaps and cosmetics as being involved in occasional but rare cases of photodermatitis. Evidence is presented documenting the safety of these agents, such as tribromsalan, trichlocarban, and hexachlorophene, for consumer use, based on a long history of successful mass marketing and the failure to elicit adverse reactions in repeat insult tests realistically conducted on animals and humans. Instances of photodermatitis implicating common topical agents are usually associated with patients possessing metabolic or genetic aberrations or exposed to undue environmental stress. Data are given of studies on guinea pigs and man which support this view.
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