Abstract

 
 
 The purpose of the study is to evaluate the effect of placental dysfunction caused by gestational endotheliopathy on the course of labor and the condition of the newborn. The first group consisted of 70 patients with placental dysfunction with gestational endotheliopathy confirmed by laboratory-instrumental findings in the first trimester of pregnancy. The control group included 30 pregnant women with physiological gestational course. PD secondary to GE leads to preterm birth, fetal distress, increases the percentage of caesarean section, contributes to the delay of fetal growth and birth weight, poor infant status and perinatal complications.
 
 
Highlights
Placental dysfunction (PD) remains one of the urgent problems of obstetrics, occuring in 15-35% of women in physiological pregnancy and in 24-80% of women with obstetric and extragenital abnormalities, reaching 40% in the structure of complications of pregnancy with no tendency to decrease and is the basis of high level of perinatal morbidity and mortality, disorders of neuropsychic development and adaptation of children [3,5,7].Despite the introduction of new methods of PD diagnosis and prevention into obstetric practice, a clear tendency to decrease its incidence is not observed, and this problem continues to be relevant in modern obstetrics
PD is characterized by a complex of disorders of trophic, transport, endocrine and metabolic function of the placenta, which underlie the development of pathology of the fetus and newborn [4, 8]
The first group consisted of 70 patients with placental dysfunction and gestational endotheliopathy confirmed by laboratory-instrumental findings (MAU greater than 5 mg albumin / mmol creatinine and EDV less than 10%) in the first trimester of pregnancy
Summary
Placental dysfunction (PD) remains one of the urgent problems of obstetrics, occuring in 15-35% of women in physiological pregnancy and in 24-80% of women with obstetric and extragenital abnormalities, reaching 40% in the structure of complications of pregnancy with no tendency to decrease and is the basis of high level of perinatal morbidity and mortality, disorders of neuropsychic development and adaptation of children [3,5,7].Despite the introduction of new methods of PD diagnosis and prevention into obstetric practice, a clear tendency to decrease its incidence is not observed, and this problem continues to be relevant in modern obstetrics. Placental dysfunction (PD) remains one of the urgent problems of obstetrics, occuring in 15-35% of women in physiological pregnancy and in 24-80% of women with obstetric and extragenital abnormalities, reaching 40% in the structure of complications of pregnancy with no tendency to decrease and is the basis of high level of perinatal morbidity and mortality, disorders of neuropsychic development and adaptation of children [3,5,7]. PD is characterized by a complex of disorders of trophic, transport, endocrine and metabolic function of the placenta, which underlie the development of pathology of the fetus and newborn [4, 8]. The nature and extent of the impact of different pathologies during pregnancy on the fetus is determined by various factors: gestation time, duration of exposure, condition of the feto-placental complex [1]
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