Abstract
<p class="Abstract">The purpose of this study was to determine the wound healing effect of Labisia pumila in the ovariectomized rat model. Ninety-nine Sprague Dawley female rats equally divided into nine groups; where five were control groups, and four were treated groups. The dressing was changed daily, starting from the wound induction until complete healing. The percentage of wound contraction was measured on day 0, 2, 5, 8, 9, 10, 11, 12 and 13. Three rats were sacrificed from each group on day 2, 5 and 8 respectively for evaluating of histological assessments. Wounds dressed with extract showed considerable healing and significantly healed faster compared to all control groups (p&lt;0.05). Moreover, histological analysis revealed remarkable reduction in the scar width correlated with the enhanced collagen content and fibroblast cells, accompanied by a reduction of inflammatory cells in the granulation tissues. In conclusion, L. pumila may promote wound healing in postmenopausal rat model.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>:</p><p class="Abstract">Ovariectomy and punch biopsy: 3 min 11 sec: <a href="https://www.youtube.com/v/IlFrHeww5Jo">Full Screen</a> <a href="https://www.youtube.com/watch?v=IlFrHeww5Jo">Alternate</a></p>
Highlights
Labisia pumila (Blume) Fern.-Vill. synonym Marantodes pumilum (Blume) Kuntze is a flowering plant of the Primulaceae family
Wounds treated with L. pumila extracts (PL, PR, AL and AR) healed on day 9, whereas, three control groups such as sham operated (SH), ovariectomized control (OC) and OV healed on the day 11
The histological analysis further revealed that wounds treated with L. pumila extracts significantly increased in re-epithelialization, fibroblast cells growth, angiogenesis, and granulation tissue formation at the later stage of wound healing process, whereas, the inflammatory cells infiltration decreased at the same time
Summary
Labisia pumila (Blume) Fern.-Vill. synonym Marantodes pumilum (Blume) Kuntze is a flowering plant of the Primulaceae family. Synonym Marantodes pumilum (Blume) Kuntze is a flowering plant of the Primulaceae family. It is used traditionally by the Malay women to shrink the uterus, facilitate labor, improve menstrual irregularities and as post-partum medicine (Runi, 2000). The ethnopharmacological studies and clinical findings have illustrated that L. pumila possesses many biological functions, including phytoestrogenic, antimicrobial, anti-oxidative, anti-inflammatory properties and anti-aging (Choi et al, 2010; Nadia et al, 2012). Recent studies on L. pumila demonstrated that it could be used for osteoporosis, cardiovascular diseases, and metabolic disorders (Shuid et al, 2011). The ethnobotanical and therapeutic properties of L. pumila make it a potential source of novel medicine for the healing of wounds. This study investigates the effectiveness of topical application of the aqueous extract of L. pumila on the rate of wound closure and the histology of the wound area
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
