LABIAL PHOTOCARCINOGENESIS

Abstract

<h3>Objectives</h3> Determine the damage caused by photocarcinogenesis in the lower lip region. <h3>Study Design</h3> We conducted a retrospective study and literature review, based on published studies on photocarcinogenesis in the labial region, to determine the damage caused by photocarcinogenesis in the lower lip region. <h3>Results</h3> The lower lip region is affected by changes caused by chronic exposure to solar radiation. Photocarcinogenesis can be considered as a process of malignant transformation caused by ultraviolet (UV) radiation. The etiology of actinic cheilitis and lip squamous cell carcinoma is attributed to mutations in DNA and damage to proteins in epithelial cells caused by the cumulative action of radiation that culminates in malignant transformation. UV radiation has both mutagenic and immunosuppressive effects, which may be able to initiate and maintain neoplastic processes, and is therefore considered a complete carcinogen. The dose, exposure time, and wavelength are closely linked to this process. <h3>Conclusions</h3> UV radiation is the most relevant etiologic factor for the occurrence of skin and lip neoplasms. Understanding the process of photocarcinogenesis in the lip region is of paramount importance for the dental surgeon to be part of the front line of early diagnosis and prevention.