Abstract
Fluorescent microspheres have been demonstrated to be useful in a variety of biologicalapplications. Fluorescent silica or polymer microspheres have been produced byincorporation of chromophores into the microspheres, which usually produces microsphereswith nonuniform sizes and reduced fluorescence. Here we present a simple andstraightforward method to produce silica microspheres with fluorescent lanthanide-dopedLaF3 nanocrystals grownon the surface. LaF3 nanocrystals are in situ grown on silica microspheres of different sizes to forma raspberry-like structure. The microspheres exhibit strong fluorescenceand the colour could be altered by changing the lanthanide ions doped inLaF3 nanocrystals.
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